Rome to Lyon bus: 2.5 a day, fastest 14h45

2.5 a dayfastest 14h45☾ 2 overnight busesBlaBlaCar Bus, FlixBus🇮🇹 Italy → 🇫🇷 France

Direct buses · no change

RomeFlorenceBolognaGenoaTurinChambéryLyon· 749 km as the crow flies

07:45 → 22:40
FlixBus 516
Rome Tiburtina Bus station → Lyon (Gerland Bus Station) · via Siena, Florence, Genoa, Turin
14h554 stops
Runs: Mon, Thu, Fri, Sat, SunBook on FlixBus ↗
08:50 → 23:45
FlixBus N521
Rome Tiburtina Bus station → Lyon (Gerland Bus Station) · via Florence, Bologna, Turin
14h554 stops
Runs: DailyBook on FlixBus ↗
15:20 → 06:05⁺¹
BlaBlaCar Bus ☾ Overnight
Rome - Tiburtina → Lyon - Gerland Bus Station · via Florence, Bologna, Turin
14h453 stops
Runs: Only Sun 25 Octthe open data has only these datesBook on BlaBlaCar Bus ↗
17:25 → 08:45⁺¹
FlixBus N580 ☾ Overnight
Rome Anagnina → Lyon (Gerland Bus Station) · via Florence, Bologna, Genoa, Turin…
15h205 stops
Runs: Wed to SunThe night the clocks change (Sat 24 Oct: 17:25 → 07:45+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and BlaBlaCar Bus (file of 18 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. Contains BlaBlaCar Bus timetable data (transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

☾ Overnight: leave 15:20, arrive 06:05

The plane is 10h02 quicker door to door, but the night bus spends your night on the road instead of a day.

Bus · fastest direct15h32

To Rome - Tiburtina15 min
At the stop before departure15 min
BlaBlaCar Bus14h45
From Lyon - Gerland Bus Station17 min

Plane · nonstop FCO to LYS5h30

To Rome Fiumicino (FCO)1h05
Check-in & security1h30
Flight FCO to LYS1h45
Landing to exit20 min
From LYS50 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance.

Train instead?

No direct train from Rome to Lyon in pickthetrain's timetables: the bus is the no-change way.

Where Rome goes by direct train ↗

Flying instead?

1 airline fly Rome to Lyon nonstop. Book on the airline's own site:

easyJetFCO→LYSBook direct ↗

Compare on picktheflight ↗

Quick answers

Is there a direct bus from Rome to Lyon?

Yes. 2.5 a day on average, with BlaBlaCar Bus and FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Rome to Lyon?

The fastest takes 14h45; the slowest 15h20, for 749 km as the crow flies.

When do the buses leave?

The earliest leaves at 07:45 and the latest at 17:25, local time in Rome. Not every bus runs every day: pick a date above.

Is there a night bus from Rome to Lyon?

Yes: 2 overnight departures in the timetable, for example 15:20 arriving 06:05 the next morning.

Rome ▸ Lyon

Direct buses · no change

Quick answers

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