Genoa ▸ Lyon
Lyon ▸ Genoa ⇄Direct buses · no change
- 02:10 → 08:45FlixBus N580 ☾ OvernightGenoa (Fanti d'Italia/Principe bus station) → Lyon (Gerland Bus Station) · via Turin, Chambéry6h352 stopsRuns: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sun 25 Oct: 02:10 → 07:45)Book on FlixBus ↗
- 10:20 → 18:10FlixBus 1501Genoa (Fanti d'Italia/Principe bus station) → Lyon (Gerland Bus Station) · via Turin, Grenoble7h502 stopsRuns: DailyBook on FlixBus ↗
- 14:00 → 00:20+1BlaBlaCar BusGenoa - Via Fanti d'Italia Bus Stop → Lyon - Gerland Bus Station · via Nice, Le Cannet, Toulon, Aix-en-Provence10h204 stopsRuns: Daily until Sat 14 Nov, not Mon 2 Nov, Tue 3 Nov, Mon 9 NovBook on BlaBlaCar Bus ↗
- 15:05 → 01:25+1FlixBus N719Genoa (Fanti d'Italia/Principe bus station) → Lyon (Gerland Bus Station) · via Nice, Le Cannet, Fréjus, Marseille10h204 stopsRuns: DailyBook on FlixBus ↗
- 15:15 → 22:40FlixBus 516Genoa (Fanti d'Italia/Principe bus station) → Lyon (Gerland Bus Station) · via Turin7h251 stopRuns: Mon, Thu, Fri, Sat, SunBook on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and BlaBlaCar Bus (file of 18 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. Contains BlaBlaCar Bus timetable data (transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Genoa to Lyon?
Yes. 4.3 a day on average, with BlaBlaCar Bus and FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Genoa to Lyon?
The fastest takes 6h35; the slowest 10h20, for 355 km as the crow flies.
When do the buses leave?
The earliest leaves at 02:10 and the latest at 15:15, local time in Genoa. Not every bus runs every day: pick a date above.
Is there a night bus from Genoa to Lyon?
Yes: 1 overnight departure in the timetable, for example 02:10 arriving 08:45.