Karlsruhe to Lyon bus: 5.8 a day, fastest 7h55

5.8 a dayfastest 7h55☾ 4 overnight busesBlaBlaCar Bus, FlixBus🇩🇪 Germany → 🇫🇷 France

Direct buses · no change

KarlsruheKehlStrasbourgColmarMulhouseBelfortLyon· 451 km as the crow flies

00:55 → 10:30
FlixBus N122 ☾ Overnight
Karlsruhe central train station → Lyon (Gerland Bus Station) · via Freiburg, Basel, Bern, Lausanne…
9h355 stops
Runs: Mon, Tue, Fri, Sat, SunThe night the clocks change (Sun 25 Oct: 00:55 → 09:30)Book on FlixBus ↗
04:05 → 12:50
FlixBus N1326
Karlsruhe central train station → Lyon (Gerland Bus Station) · via Kehl, Strasbourg, Colmar, Mulhouse…
8h457 stops
Runs: DailyThe night the clocks change (Sun 25 Oct: 03:05 → 11:50)Book on FlixBus ↗
10:25 → 20:50
FlixBus 122
Karlsruhe central train station → Lyon (Gerland Bus Station) · via Freiburg, Basel, Bern, Lausanne…
10h255 stops
Runs: DailyBook on FlixBus ↗
11:15 → 20:45
BlaBlaCar Bus
Karlsruhe - Central Station South Side → Lyon - Gerland Bus Station · via Strasbourg, Nancy
9h302 stops
Runs: Wed, Fri, Sun (some weeks)Book on BlaBlaCar Bus ↗
15:20 → 23:15
FlixBus N1316
Karlsruhe central train station → Lyon (Gerland Bus Station) · via Strasbourg, Besançon, Chalon-sur-Saône
7h553 stops
Runs: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sun 25 Oct: 14:20 → 22:15)Book on FlixBus ↗
20:20 → 04:20⁺¹
FlixBus N1135 ☾ Overnight
Karlsruhe central train station → Lyon (Gerland Bus Station) · via Strasbourg, Freiburg, Mulhouse
8h003 stops
Runs: Mon, Tue, Fri, Sat, SunThe night the clocks change (Sat 24 Oct: 20:20 → 03:20+1)Book on FlixBus ↗
21:05 → 05:10⁺¹
BlaBlaCar Bus ☾ Overnight
Karlsruhe - Central Station South Side → Lyon - Gerland Bus Station · via Strasbourg, Colmar, Mulhouse
8h053 stops
Runs: Thu, Fri, SunBook on BlaBlaCar Bus ↗
23:55 → 08:15⁺¹
FlixBus N1315 ☾ Overnight
Karlsruhe central train station → Lyon (Gerland Bus Station) · via Strasbourg, Colmar, Mulhouse, Belfort…
8h205 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 23:55 → 07:15+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and BlaBlaCar Bus (file of 18 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. Contains BlaBlaCar Bus timetable data (transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

Fastest door to door: the train (4h57). The bus takes 3h44 longer.

Bus · fastest direct8h41

To Karlsruhe central train station14 min
At the stop before departure15 min
FlixBus N13167h55
From Lyon (Gerland Bus Station)17 min

Train · fastest direct4h57

To Karlsruhe Hbf1 min
Before departure10 min
671A4h46

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

1 a daydirect trains, fastest 4h46

Société Nationale des Chemins de fer Français. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

Nothing flies Karlsruhe to Lyon nonstop in picktheflight's airline data.

Check flights on picktheflight ↗

Quick answers

Is there a direct bus from Karlsruhe to Lyon?

Yes. 5.8 a day on average, with BlaBlaCar Bus and FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Karlsruhe to Lyon?

The fastest takes 7h55; the slowest 10h25, for 451 km as the crow flies.

When do the buses leave?

The earliest leaves at 00:55 and the latest at 23:55, local time in Karlsruhe. Not every bus runs every day: pick a date above.

Is there a night bus from Karlsruhe to Lyon?

Yes: 4 overnight departures in the timetable, for example 00:55 arriving 10:30.

Karlsruhe ▸ Lyon

Direct buses · no change

Quick answers

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