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Lyon ▸ Karlsruhe

Karlsruhe ▸ Lyon ⇄
5.8 a dayfastest 7h55☾ 3 overnight busesBlaBlaCar Bus, FlixBus🇫🇷 France → 🇩🇪 Germany

Direct buses · no change

LyonBesançonMontbéliardBelfortMulhouseColmarKarlsruhe· 451 km as the crow flies
  • 02:05 → 10:50
    BlaBlaCar Bus ☾ Overnight
    Lyon - Gerland Bus Station → Karlsruhe - Central Station South Side · via Nancy, Strasbourg
    8h452 stops
    Runs: Mon, Thu (some weeks)Book on BlaBlaCar Bus ↗
  • 03:10 → 11:05
    FlixBus N1135
    Lyon (Gerland Bus Station) → Karlsruhe central train station · via Mulhouse, Freiburg, Strasbourg
    7h553 stops
    Runs: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sun 25 Oct: 02:10 → 10:05)Book on FlixBus ↗
  • 03:20 → 11:35
    BlaBlaCar Bus
    Lyon - Gerland Bus Station → Karlsruhe - Central Station South Side · via Mulhouse, Colmar, Strasbourg
    8h153 stops
    Runs: Tue, Sat, Sun (some weeks)The night the clocks change (Sun 25 Oct: 02:20 → 10:35)Book on BlaBlaCar Bus ↗
  • 05:20 → 13:15
    FlixBus N1316
    Lyon (Gerland Bus Station) → Karlsruhe central train station · via Chalon-sur-Saône, Besançon, Strasbourg
    7h553 stops
    Runs: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
  • 07:30 → 18:00
    FlixBus 122
    Lyon (Gerland Bus Station) → Karlsruhe central train station · via Geneva, Lausanne, Bern, Basel…
    10h305 stops
  • 17:05 → 01:50+1
    FlixBus N1326
    Lyon (Gerland Bus Station) → Karlsruhe central train station · via Besançon, Montbéliard, Belfort, Mulhouse…
    8h457 stops
  • 22:00 → 06:20+1
    FlixBus N1315 ☾ Overnight
    Lyon (Gerland Bus Station) → Karlsruhe central train station · via Chalon-sur-Saône, Belfort, Mulhouse, Colmar…
    8h205 stops
    Runs: DailyThe night the clocks change (Sat 24 Oct: 22:00 → 05:20+1)Book on FlixBus ↗
  • 23:00 → 08:10+1
    FlixBus N122 ☾ Overnight
    Lyon (Gerland Bus Station) → Karlsruhe central train station · via Geneva, Lausanne, Bern, Basel…
    9h105 stops
    Runs: Mon, Tue, Fri, Sat, SunThe night the clocks change (Sat 24 Oct: 23:00 → 07:10+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and BlaBlaCar Bus (file of 18 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. Contains BlaBlaCar Bus timetable data (transport.data.gouv.fr), ODbL 1.0. How we build this.

Quick answers

Is there a direct bus from Lyon to Karlsruhe?

Yes. 5.8 a day on average, with BlaBlaCar Bus and FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Lyon to Karlsruhe?

The fastest takes 7h55; the slowest 10h30, for 451 km as the crow flies.

When do the buses leave?

The earliest leaves at 02:05 and the latest at 23:00, local time in Lyon. Not every bus runs every day: pick a date above.

Is there a night bus from Lyon to Karlsruhe?

Yes: 3 overnight departures in the timetable, for example 02:05 arriving 10:50.