Milan to Karlsruhe bus: 5.5 a day, fastest 7h20

5.5 a dayfastest 7h20☾ 4 overnight busesFlixBus🇮🇹 Italy → 🇩🇪 Germany

Direct buses · no change

MilanComoLuganoZurichStuttgartKarlsruhe· 399 km as the crow flies

01:15 → 11:10
FlixBus N77 ☾ Overnight
Milan (Lampugnano bus station) → Karlsruhe central train station · via Bregenz, Ulm, Stuttgart
9h553 stops
Runs: DailyThe night the clocks change (Sun 25 Oct: 01:15 → 10:10)Book on FlixBus ↗
07:15 → 15:35
FlixBus 476
Milan (Lampugnano bus station) → Karlsruhe central train station · via Zurich, Lörrach, Freiburg
8h203 stops
Runs: Mon, Thu, Fri, Sat, Sun (some weeks)Book on FlixBus ↗
10:50 → 21:00
FlixBus 024
Milan (Lampugnano bus station) → Karlsruhe central train station · via Como, Lugano, Zurich, Stuttgart
10h106 stops
Runs: Mon, Thu, Fri, Sat, SunBook on FlixBus ↗
19:00 → 03:10⁺¹
FlixBus N07 ☾ Overnight
Milan (Lampugnano bus station) → Karlsruhe central train station · via Zurich, Freiburg
8h102 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 19:00 → 02:10+1)Book on FlixBus ↗
20:25 → 03:45⁺¹
FlixBus N487 ☾ Overnight
Milan (Lampugnano bus station) → Karlsruhe central train station · via Basel
7h201 stop
Runs: DailyThe night the clocks change (Sat 24 Oct: 20:25 → 02:45+1)Book on FlixBus ↗
23:45 → 08:20⁺¹
FlixBus N177 ☾ Overnight
Milan (Lampugnano bus station) → Karlsruhe central train station · via Zurich, Tübingen, Stuttgart
8h353 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 23:45 → 07:20+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

☾ Overnight: leave 20:25, arrive 03:45

The train is 1h40 quicker door to door, but the night bus spends your night on the road instead of a day.

Bus · fastest direct8h11

To Milan (Lampugnano bus station)22 min
At the stop before departure15 min
FlixBus N4877h20
From Karlsruhe central train station14 min

Train · fastest direct6h31

To Milano Centrale1 min
Before departure10 min
EC 1506h19
From Karlsruhe Hbf1 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

1 a daydirect trains, fastest 6h19

Trenitalia. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

Nothing flies Milan to Karlsruhe nonstop in picktheflight's airline data.

Check flights on picktheflight ↗

Quick answers

Is there a direct bus from Milan to Karlsruhe?

Yes. 5.5 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Milan to Karlsruhe?

The fastest takes 7h20; the slowest 10h10, for 399 km as the crow flies.

When do the buses leave?

The earliest leaves at 01:15 and the latest at 23:45, local time in Milan. Not every bus runs every day: pick a date above.

Is there a night bus from Milan to Karlsruhe?

Yes: 4 overnight departures in the timetable, for example 01:15 arriving 11:10.

Milan ▸ Karlsruhe

Direct buses · no change

Quick answers

More from Milan

More to Karlsruhe