Karlsruhe to Milan bus: 5.5 a day, fastest 7h20

5.5 a dayfastest 7h20☾ 2 overnight busesFlixBus🇩🇪 Germany → 🇮🇹 Italy

Direct buses · no change

KarlsruheStuttgartZurichAltdorfLuganoComoMilan· 399 km as the crow flies

03:20 → 11:15
FlixBus N07
Karlsruhe central train station → Milan (Lampugnano bus station) · via Freiburg, Zurich
7h552 stops
Runs: DailyThe night the clocks change (Sun 25 Oct: 02:20 → 10:15)Book on FlixBus ↗
07:40 → 17:50
FlixBus 024
Karlsruhe central train station → Milan (Lampugnano bus station) · via Stuttgart, Zurich, Altdorf, Lugano…
10h108 stops
Runs: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
09:30 → 16:50
FlixBus N487
Karlsruhe central train station → Milan (Lampugnano bus station) · via Basel
7h201 stop
Runs: DailyThe night the clocks change (Sun 25 Oct: 08:30 → 15:50)Book on FlixBus ↗
11:05 → 19:15
FlixBus 476
Karlsruhe central train station → Milan (Lampugnano bus station) · via Freiburg, Lörrach, Zurich
8h103 stops
Runs: Mon, Tue, Fri, Sat, Sun (some weeks)Book on FlixBus ↗
20:10 → 05:05⁺¹
FlixBus N77 ☾ Overnight
Karlsruhe central train station → Milan (Lampugnano bus station) · via Stuttgart, Ulm, Bregenz
8h553 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 20:10 → 04:05+1)Book on FlixBus ↗
23:00 → 07:10⁺¹
FlixBus N177 ☾ Overnight
Karlsruhe central train station → Milan (Lampugnano bus station) · via Stuttgart, Tübingen, Zurich
8h103 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 23:00 → 06:10+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

Fastest door to door: the train (6h51). The bus takes 1h20 longer.

Bus · fastest direct8h11

To Karlsruhe central train station14 min
At the stop before departure15 min
FlixBus N4877h20
From Milan (Lampugnano bus station)22 min

Train · fastest direct6h51

To Karlsruhe Hbf1 min
Before departure10 min
EC 1516h39
From Milano Centrale1 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

1 a daydirect trains, fastest 6h39

Trenitalia. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Flying instead?

Nothing flies Karlsruhe to Milan nonstop in picktheflight's airline data.

Check flights on picktheflight ↗

Quick answers

Is there a direct bus from Karlsruhe to Milan?

Yes. 5.5 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Karlsruhe to Milan?

The fastest takes 7h20; the slowest 10h10, for 399 km as the crow flies.

When do the buses leave?

The earliest leaves at 03:20 and the latest at 23:00, local time in Karlsruhe. Not every bus runs every day: pick a date above.

Is there a night bus from Karlsruhe to Milan?

Yes: 2 overnight departures in the timetable, for example 20:10 arriving 05:05 the next morning.

Karlsruhe ▸ Milan

Direct buses · no change

Quick answers

More from Karlsruhe

More to Milan