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Direct buses › From Rome

Rome ▸ Prague

Prague ▸ Rome ⇄
1 a dayfastest 20h40☾ 1 overnight busFlixBus🇮🇹 Italy → 🇨🇿 Czechia

Direct buses · no change

RomeFlorenceBolognaPaduaMestrePortogruaroPrague· 923 km as the crow flies
  • 17:05 → 13:45+1
    FlixBus N1533 ☾ Overnight
    Rome Tiburtina Bus station → Prague (Main Railway Station) · via Florence, Bologna, Padua, Mestre…
    20h4010 stops
    Runs: DailyThe night the clocks change (Sat 24 Oct: 17:05 → 12:45+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Quick answers

Is there a direct bus from Rome to Prague?

Yes. 1 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Rome to Prague?

The fastest takes 20h40; the slowest 20h40, for 923 km as the crow flies.

Is there a night bus from Rome to Prague?

Yes: 1 overnight departure in the timetable, for example 17:05 arriving 13:45 the next morning.

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