Mestre ▸ Karlsruhe
Karlsruhe ▸ Mestre ⇄1.4 a dayfastest 12h05☾ 2 overnight busesFlixBus🇮🇹 Italy → 🇩🇪 Germany
Direct buses · no change
MestreVeniceVeronaTrentoBolzanoMunichKarlsruhe· 487 km as the crow flies
- 16:45 → 05:45+1FlixBus N277 ☾ OvernightVenice (Marco Polo Airport) → Karlsruhe central train station · via Venice, Verona, Trento, Bolzano…13h008 stopsRuns: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sat 24 Oct: 16:45 → 04:45+1)Book on FlixBus ↗
- 17:40 → 05:45+1FlixBus N277 ☾ OvernightVenice Mestre (Stazione FS) → Karlsruhe central train station · via Verona, Trento, Bolzano, Munich…12h056 stopsRuns: Mon, Thu, Fri, Sat, SunThe night the clocks change (Sat 24 Oct: 17:40 → 04:45+1)Book on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Mestre to Karlsruhe?
Yes. 1.4 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Mestre to Karlsruhe?
The fastest takes 12h05; the slowest 13h00, for 487 km as the crow flies.
When do the buses leave?
The earliest leaves at 16:45 and the latest at 17:40, local time in Mestre. Not every bus runs every day: pick a date above.
Is there a night bus from Mestre to Karlsruhe?
Yes: 2 overnight departures in the timetable, for example 16:45 arriving 05:45 the next morning.