Karlsruhe ▸ Plzeň
Plzeň ▸ Karlsruhe ⇄1.8 a dayfastest 6h35☾ 1 overnight busFlixBus🇩🇪 Germany → 🇨🇿 Czechia
Direct buses · no change
KarlsruheStuttgartHeilbronnNurembergPlzeň· 369 km as the crow flies
- 06:25 → 13:50FlixBus N1315Karlsruhe central train station → Plzeň (central bus station) · via Stuttgart, Heilbronn, Nuremberg7h257 stops
- 23:25 → 06:00+1FlixBus N168 ☾ OvernightKarlsruhe central train station → Plzeň (central bus station) · via Stuttgart, Heilbronn, Nuremberg6h356 stopsRuns: Mon, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 23:25 → 05:00+1)Book on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Karlsruhe to Plzeň?
Yes. 1.8 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Karlsruhe to Plzeň?
The fastest takes 6h35; the slowest 7h25, for 369 km as the crow flies.
When do the buses leave?
The earliest leaves at 06:25 and the latest at 23:25, local time in Karlsruhe. Not every bus runs every day: pick a date above.
Is there a night bus from Karlsruhe to Plzeň?
Yes: 1 overnight departure in the timetable, for example 23:25 arriving 06:00 the next morning.