Frankfurt ▸ Florence
Florence ▸ Frankfurt ⇄1.6 a dayfastest 14h15☾ 2 overnight busesFlixBus🇩🇪 Germany → 🇮🇹 Italy
Direct buses · no change
FrankfurtMannheimKarlsruheStuttgartUlmBregenzFlorence· 731 km as the crow flies
- 17:45 → 10:25+1FlixBus N77 ☾ OvernightFrankfurt central train station → Florence (Villa Costanza) · via Mannheim, Karlsruhe, Stuttgart, Ulm…16h407 stops
- 22:30 → 12:45+1FlixBus N537 ☾ OvernightFrankfurt central train station → Florence (Villa Costanza) · via Innsbruck, Bolzano, Trento, Verona…14h155 stopsRuns: Mon, Thu, Fri, SunBook on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Frankfurt to Florence?
Yes. 1.6 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Frankfurt to Florence?
The fastest takes 14h15; the slowest 16h40, for 731 km as the crow flies.
When do the buses leave?
The earliest leaves at 17:45 and the latest at 22:30, local time in Frankfurt. Not every bus runs every day: pick a date above.
Is there a night bus from Frankfurt to Florence?
Yes: 2 overnight departures in the timetable, for example 17:45 arriving 10:25 the next morning.