Prague to Mannheim bus: 3 a day, fastest 6h45

3 a dayfastest 6h45☾ 1 overnight busFlixBus🇨🇿 Czechia → 🇩🇪 Germany

Direct buses · no change

PragueNurembergWolpertshausenNeckarsulmHeidelbergMannheim· 432 km as the crow flies

07:35 → 15:35
FlixBus 109
Prague (Central Bus Station Florenc) → Mannheim central bus station · via Nuremberg, Wolpertshausen, Heidelberg
8h006 stops
Runs: DailyBook on FlixBus ↗
17:15 → 01:05⁺¹
FlixBus N109
Prague (Central Bus Station Florenc) → Mannheim central bus station · via Nuremberg, Wolpertshausen, Neckarsulm, Heidelberg
7h506 stops
Runs: DailyBook on FlixBus ↗
20:15 → 03:00⁺¹
FlixBus N1309 ☾ Overnight
Prague (Central Bus Station Florenc) → Mannheim central bus station · via Nuremberg
6h452 stops
Runs: DailyThe night the clocks change (Sat 24 Oct: 20:15 → 02:00+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

The bus is the fastest way door to door

Bus · fastest direct7h26

To Prague (Central Bus Station Florenc)13 min
At the stop before departure15 min
FlixBus N13096h45
From Mannheim central bus station13 min

Train · fastest direct10h00

To Praha hlavní nádraží1 min
Before departure10 min
EC 4589h49

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

1 a daydirect trains, fastest 9h49

České dráhy. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Quick answers

Is there a direct bus from Prague to Mannheim?

Yes. 3 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Prague to Mannheim?

The fastest takes 6h45; the slowest 8h00, for 432 km as the crow flies.

When do the buses leave?

The earliest leaves at 07:35 and the latest at 20:15, local time in Prague. Not every bus runs every day: pick a date above.

Is there a night bus from Prague to Mannheim?

Yes: 1 overnight departure in the timetable, for example 20:15 arriving 03:00 the next morning.

Prague ▸ Mannheim

Direct buses · no change

Quick answers

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