Mannheim to Prague bus: 3 a day, fastest 7h10

3 a dayfastest 7h10FlixBus🇩🇪 Germany → 🇨🇿 Czechia

Direct buses · no change

MannheimHeidelbergNeckarsulmWolpertshausenNurembergPrague· 432 km as the crow flies

03:25 → 10:35
FlixBus N1309
Mannheim central bus station → Prague (Central Bus Station Florenc) · via Nuremberg
7h102 stops
Runs: DailyThe night the clocks change (Sun 25 Oct: 02:25 → 09:35)Book on FlixBus ↗
05:20 → 13:05
FlixBus N109
Mannheim central bus station → Prague (Central Bus Station Florenc) · via Heidelberg, Neckarsulm, Wolpertshausen, Nuremberg
7h457 stops
Runs: DailyThe night the clocks change (Sun 25 Oct: 04:20 → 12:05)Book on FlixBus ↗
15:35 → 23:10
FlixBus 109
Mannheim central bus station → Prague (Central Bus Station Florenc) · via Heidelberg, Wolpertshausen, Nuremberg
7h356 stops
Runs: Mon to FriBook on FlixBus ↗
15:50 → 23:10
FlixBus 109
Mannheim central bus station → Prague (Central Bus Station Florenc) · via Heidelberg, Wolpertshausen, Nuremberg
7h206 stops
Runs: Sat, SunBook on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Bus, train or plane

The bus is the fastest way door to door

Bus · fastest direct7h51

To Mannheim central bus station13 min
At the stop before departure15 min
FlixBus N13097h10
From Prague (Central Bus Station Florenc)13 min

Train · fastest direct9h46

Before departure10 min
EC 4599h35
From Praha hlavní nádraží1 min

City centre to city centre. Getting to stops, stations and airports: typical public-transport times (estimates). Bus: be at the stop 15 min before. Plane: check-in and security 1h30 before, then getting out after landing; flight time typical for the distance. Train: pickthetrain's door-to-door time.

Train instead?

6 a weekdirect trains, fastest 9h35

Deutsche Bahn. No change of train, from the operators' official timetables.

See the trains on pickthetrain ↗

Quick answers

Is there a direct bus from Mannheim to Prague?

Yes. 3 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Mannheim to Prague?

The fastest takes 7h10; the slowest 7h45, for 432 km as the crow flies.

When do the buses leave?

The earliest leaves at 03:25 and the latest at 15:50, local time in Mannheim. Not every bus runs every day: pick a date above.

Is there a night bus from Mannheim to Prague?

Not an overnight one: every bus here travels by day or evening.

Mannheim ▸ Prague

Direct buses · no change

Quick answers

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