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Direct buses › From Frankfurt

Frankfurt ▸ Milan

Milan ▸ Frankfurt ⇄
4.8 a dayfastest 9h35☾ 2 overnight busesFlixBus🇩🇪 Germany → 🇮🇹 Italy

Direct buses · no change

FrankfurtMannheimHeidelbergKarlsruheFreiburgZurichMilan· 519 km as the crow flies
  • 00:45 → 11:15
    FlixBus N07 ☾ Overnight
    Frankfurt central train station → Milan (Lampugnano bus station) · via Mannheim, Heidelberg, Karlsruhe, Freiburg…
    10h308 stops
    Runs: DailyThe night the clocks change (Sun 25 Oct: 00:45 → 10:15)Book on FlixBus ↗
  • 07:15 → 16:50
    FlixBus N487
    Frankfurt central train station → Milan (Lampugnano bus station) · via Mannheim, Karlsruhe, Basel
    9h353 stops
    Runs: DailyThe night the clocks change (Sun 25 Oct: 06:15 → 15:50)Book on FlixBus ↗
  • 08:30 → 19:15
    FlixBus 476
    Frankfurt central train station → Milan (Lampugnano bus station) · via Heidelberg, Karlsruhe, Freiburg, Lörrach…
    10h457 stops
    Runs: Mon, Tue, Fri, Sat, Sun (some weeks)Book on FlixBus ↗
  • 11:00 → 22:00
    FlixBus 107
    Frankfurt central train station → Milan (Lampugnano bus station) · via Heidelberg, Freiburg, Basel, Zurich
    11h006 stops
    Runs: DailyBook on FlixBus ↗
  • 17:45 → 05:05+1
    FlixBus N77 ☾ Overnight
    Frankfurt central train station → Milan (Lampugnano bus station) · via Mannheim, Karlsruhe, Stuttgart, Ulm…
    11h205 stops
    Runs: DailyThe night the clocks change (Sat 24 Oct: 17:45 → 04:05+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Quick answers

Is there a direct bus from Frankfurt to Milan?

Yes. 4.8 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Frankfurt to Milan?

The fastest takes 9h35; the slowest 11h20, for 519 km as the crow flies.

When do the buses leave?

The earliest leaves at 00:45 and the latest at 17:45, local time in Frankfurt. Not every bus runs every day: pick a date above.

Is there a night bus from Frankfurt to Milan?

Yes: 2 overnight departures in the timetable, for example 00:45 arriving 11:15.

More from Frankfurt

Every bus from Frankfurt

More to Milan

Every bus from Milan