Strasbourg ▸ Prague
Prague ▸ Strasbourg ⇄3.5 a dayfastest 10h00☾ 1 overnight busFlixBus🇫🇷 France → 🇨🇿 Czechia
Direct buses · no change
StrasbourgBaden-BadenKarlsruheStuttgartNurembergZwickauPrague· 512 km as the crow flies
- 04:50 → 15:25FlixBus N1315Strasbourg → Prague (Central Bus Station Florenc) · via Karlsruhe, Stuttgart, Heilbronn, Nuremberg…10h359 stops
- 10:40 → 22:40FlixBus 321 / 321AStrasbourg → Prague (Central Bus Station Florenc) · via Baden-Baden, Karlsruhe, Stuttgart, Nuremberg…12h0010 stopsRuns: DailyBook on FlixBus ↗
- 11:50 → 21:50FlixBus N1316Strasbourg → Prague (Central Bus Station Florenc) · via Karlsruhe, Stuttgart, Heilbronn, Nuremberg…10h009 stopsRuns: Mon, Tue, Fri, Sat, SunBook on FlixBus ↗
- 21:45 → 07:50+1FlixBus N168 ☾ OvernightStrasbourg → Prague (Central Bus Station Florenc) · via Kehl, Baden-Baden, Karlsruhe, Stuttgart…10h0512 stopsRuns: Mon, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 21:45 → 06:50+1)Book on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Strasbourg to Prague?
Yes. 3.5 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Strasbourg to Prague?
The fastest takes 10h00; the slowest 12h00, for 512 km as the crow flies.
When do the buses leave?
The earliest leaves at 04:50 and the latest at 21:45, local time in Strasbourg. Not every bus runs every day: pick a date above.
Is there a night bus from Strasbourg to Prague?
Yes: 1 overnight departure in the timetable, for example 21:45 arriving 07:50 the next morning.