Prague ▸ Lausanne
Lausanne ▸ Prague ⇄1.9 a dayfastest 12h20☾ 2 overnight busesFlixBus🇨🇿 Czechia → 🇨🇭 Switzerland
Direct buses · no change
PragueMunichMemmingenLindauBregenzSt. GallenLausanne· 699 km as the crow flies
- 16:15 → 05:40+1FlixBus N106 ☾ OvernightPrague (Main Railway Station) → Lausanne (P+R Vélodrome) · via Munich, Memmingen, Lindau, Bregenz…13h257 stopsRuns: Mon, Thu, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 16:15 → 04:40+1)Book on FlixBus ↗
- 19:30 → 07:50+1FlixBus N872 ☾ OvernightPrague (Central Bus Station Florenc) → Lausanne (P+R Vélodrome) · via Nuremberg, Freiburg, Basel, Bern12h204 stops
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Prague to Lausanne?
Yes. 1.9 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Prague to Lausanne?
The fastest takes 12h20; the slowest 13h25, for 699 km as the crow flies.
When do the buses leave?
The earliest leaves at 16:15 and the latest at 19:30, local time in Prague. Not every bus runs every day: pick a date above.
Is there a night bus from Prague to Lausanne?
Yes: 2 overnight departures in the timetable, for example 16:15 arriving 05:40 the next morning.