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Direct buses › From Prague

Prague ▸ Brussels

Brussels ▸ Prague ⇄
3.5 a dayfastest 13h29☾ 2 overnight busesFlixBus🇨🇿 Czechia → 🇧🇪 Belgium

Direct buses · no change

PragueNurembergErlangenFrankfurtBonnCologneBrussels· 717 km as the crow flies
  • 03:25 → 17:55
    FlixBus N1310
    Prague (Main Railway Station) → Brussels-North train station · via Nuremberg, Erlangen, Frankfurt, Mainz…
    14h308 stops
    Runs: DailyThe night the clocks change (Sun 25 Oct: 02:25 → 16:55)Book on FlixBus ↗
  • 09:45 → 23:15
    FlixBus N870
    Prague (Central Bus Station Florenc) → Brussels-North train station · via Nuremberg, Frankfurt, Cologne, Maastricht
    13h304 stops
    Runs: Only Sun 8 Nov, Mon 9 Nov, Tue 10 Nov, Wed 11 Nov, Thu 12 NovBook on FlixBus ↗
  • 10:30 → 23:59
    FlixBus N870
    Prague (Central Bus Station Florenc) → Brussels-North train station · via Nuremberg, Frankfurt, Cologne, Maastricht
    13h294 stops
    Runs: Only Sat 24 Oct, Sat 31 Oct, Sat 7 Nov, Sat 14 NovBook on FlixBus ↗
  • 11:00 → 00:30+1
    FlixBus N870
    Prague (Central Bus Station Florenc) → Brussels-North train station · via Nuremberg, Frankfurt, Cologne, Maastricht
    13h304 stops
    Runs: Daily except Sat (some weeks)Book on FlixBus ↗
  • 16:15 → 07:20+1
    FlixBus N84 ☾ Overnight
    Prague (Central Bus Station Florenc) → Brussels South (Gare du Midi) · via Nuremberg, Erlangen, Frankfurt, Bonn…
    15h0510 stops
    Runs: DailyThe night the clocks change (Sat 24 Oct: 16:15 → 06:20+1)Book on FlixBus ↗
  • 23:05 → 13:55+1
    FlixBus N84 ☾ Overnight
    Prague (Central Bus Station Florenc) → Brussels South (Gare du Midi) · via Nuremberg, Würzburg, Frankfurt, Bonn…
    14h5010 stops
    Runs: Daily until Sat 31 OctThe night the clocks change (Sat 24 Oct: 23:05 → 12:55+1)Book on FlixBus ↗

Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026) and FlixBus UK (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.

Quick answers

Is there a direct bus from Prague to Brussels?

Yes. 3.5 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).

How long is the bus from Prague to Brussels?

The fastest takes 13h29; the slowest 15h05, for 717 km as the crow flies.

When do the buses leave?

The earliest leaves at 03:25 and the latest at 23:05, local time in Prague. Not every bus runs every day: pick a date above.

Is there a night bus from Prague to Brussels?

Yes: 2 overnight departures in the timetable, for example 16:15 arriving 07:20 the next morning.

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