Düsseldorf ▸ Prague
Prague ▸ Düsseldorf ⇄3.6 a dayfastest 10h40☾ 1 overnight busFlixBus🇩🇪 Germany → 🇨🇿 Czechia
Direct buses · no change
DüsseldorfLeverkusenSiegenGießenAlsfeldErfurtPrague· 553 km as the crow flies
- 07:15 → 19:10FlixBus 020Düsseldorf central bus station → Prague (Central Bus Station Florenc) · via Leverkusen, Siegen, Gießen, Alsfeld…11h559 stopsRuns: Mon, Tue, Fri, Sat, Sun (some weeks)Book on FlixBus ↗
- 07:30 → 19:35FlixBus 084Düsseldorf central bus station → Prague (Central Bus Station Florenc) · via Cologne, Frankfurt, Wertheim, Würzburg…12h058 stopsRuns: DailyBook on FlixBus ↗
- 09:15 → 21:30FlixBus 084Düsseldorf central bus station → Prague (Central Bus Station Florenc) · via Leverkusen, Cologne, Frankfurt, Würzburg…12h157 stopsRuns: Daily until Sat 14 Nov, not Mon 9 Nov, Tue 10 Nov, Wed 11 NovBook on FlixBus ↗
- 23:30 → 10:10+1FlixBus N23 ☾ OvernightDüsseldorf central bus station → Prague (Central Bus Station Florenc) · via Essen, Bochum, Dortmund, Halle…10h406 stopsRuns: Mon, Thu, Fri, Sat, Sun (some weeks)The night the clocks change (Sat 24 Oct: 23:30 → 09:10+1)Book on FlixBus ↗
Local times at each stop. Times from official open data: FlixBus (file of 11 Oct 2026). Checked Sun 18 Oct 2026; they cover 18 Oct to 14 Nov 2026. Timetables change, so check with the operator before you travel. Contains FlixBus timetable data (FlixMobility, transport.data.gouv.fr), ODbL 1.0. How we build this.
Quick answers
Is there a direct bus from Düsseldorf to Prague?
Yes. 3.6 a day on average, with FlixBus, no change of bus (18 Oct to 14 Nov 2026).
How long is the bus from Düsseldorf to Prague?
The fastest takes 10h40; the slowest 12h15, for 553 km as the crow flies.
When do the buses leave?
The earliest leaves at 07:15 and the latest at 23:30, local time in Düsseldorf. Not every bus runs every day: pick a date above.
Is there a night bus from Düsseldorf to Prague?
Yes: 1 overnight departure in the timetable, for example 23:30 arriving 10:10 the next morning.